(2014) “3D Live Fluorescence Imaging of Cellular Dynamics Using Bessel Beam Plane Illumination Microscopy”, Nature Protocols, 9, 1083-1011. (2016) “Imaging multicellular specimens with real-time optimized tiling light sheet selective plane illumination microscopy”, Nature Communications, 7:11088.ģ. (*Corresponding Author)Ģ. Fu, Q., Martin, B., Matus, D., Gao, L. * (2020) “A Versatile Tiling Light Sheet Microscope for Imaging of Cleared Tissues”, Cell Reports, 33:108349. It allows efficient ion introduction from atmospheric pressure environments to high vacuum environments with very limited pumping capacities.ġ. Chen, Y.L., Li, X.L., Zhang, D.D., Wang, C.H., Feng, R.L., Li, X.Z., Wen, Y., Xu, H., Zhang, Shirley X.Y., Yang, X., Chen, Y.Y., Feng, Y., Zhou, B., Chen, B.C., Lei, K., Cai S., * Jia, J.M., * Gao, L. ( )Ĭhemical & Engineering News / Science & Technology / Concentrates, “Interface boosts MS performance”, May 19, 2008, 86(20), 39-40.Ī news report about a discontinuous atmospheric pressure interface (DAPI, patented) I invented in the Purdue University during my Ph.D. The rover will be sent to the Mars in July 2020. Our invention, the discontinuous atmospheric pressure interface (DAPI), was used in the Mars Organic Molecule Analyzer (MOMA) of the latest ExoMars rover, “ROSALIND FRANKLIN”, to introduce ions from the Mars atmosphere to the mass analyzer vacuum chamber. It is the first light sheet microscopy technique that allows low invasive, high speed 3D fluorescence imaging of biological processes at submicron isotropic 3D spatial resolution.ĭPAI used in the ExoMars rover “ROSALIND FRANKLIN” Eric Betzig in the Janelia Research Campus of HHMI during my postdoctoral research. HHMI News, “New microscope produces dazzling 3D movies of live cells”, March 04, 2011.Įditor reviews and news reports on the Bessel beam plane illumination microscopy technique I worked on with Dr. Nature Biotechnology, “Bessel beams for light relief”, 2011, 29(4).īBC News, “Light sheets image life in 3D”. Nature, “Seeing cells with sheets of light”, 2011, 471, 268. Nature Methods, “Imaging life with thin sheets of light”, 2012, 9(1). It is the first light sheet microscopy technique that allows high speed, live 3D fluorescence imaging beyond the diffraction limit. Nature Methods, “Bessel beams beyond the limit”, 2013, 10Īn editor review on the Bessel beam structured illumination microscopy technique I developed with Dr. The technique is under commercialization by multiple companies. It is an effective light sheet microscopy technique enables low invasive 3D fluorescence imaging of multicellular specimens at high spatial and temporal resolution. Nature Methods, “Tunable light sheet microscopy”, 2016, 6Īn editor review about the tiling light sheet selective plane illumination microscopy (TLS-SPIM, patented) developed in my lab at the Stony Brook University. Intelligent Imaging Innovations, Inc., Cleared Tiling Lightsheet microscope.Nuohai Life Science, LS18 light sheet microscope.elegans embryos, zebrafish embryos and mouse embryos as animal models.Ģ. High resolution, high throughput 3D imaging and interpretation of tissue structures.ģ. High throughput, quantitative analysis of large size biomedical 3D images.Ĭommercial Microscopes use our technology We are specifically interested in the following research directions at this moment.ġ. Quantitative understanding of cell behaviors in multicellular environments using c. Our current research is focused on the development of novel fluorescence imaging techniques and quantitative image analysis methods, in order to image biological processes at high spatial and temporal resolution and understand biological behaviors and structures quantitatively. from 2017 to 2018 before he joined the Westlake University as an associate professor in 2019. He was an assistant professor in the State University of New York at Stony Brook from 2014 to 2016 and a lead research scientist in the Intelligent Imaging Innovations, Inc. Eric Betzig in the Janelia Research Campus of the Howard Hughes Medical Institute from 2010 to 2013. He did his postdoctoral research with Dr. Graham Cooks from the Purdue University in 2009. degree from the Tsinghua University in 20.
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